VBCN - April 2016 Volume 3, No 1

The annual direct medical costs of patients with chronic migraine approach $5000, and the costs associated with lost productivity exceed $3000 annually.
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Neurologist-directed ambulatory care for chronic neurologic diseases resulted in higher costs but fewer adverse events and less use of acute care services, according to an American Academy of Neurology–supported study.
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Patients with drug-refractory tardive dyskinesia had significant and durable symptomatic improvement after bilateral deep-brain stimulation, a small clinical study showed.
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The monoclonal antibody ocreliz­umab was recently granted a breakthrough therapy designation by the FDA for the treatment of patients with primary progressive multiple sclerosis (PPMS).
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Ozanimod, an oral modulator of the sphingosine1-phosphate (S1P) receptor, was effective up to 72 weeks in a blinded extension of the phase 2/3 RADIANCE clinical trial that included patients with relapsing forms of multiple sclerosis (MS).
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Could stem-cell transplantation prove equally efficacious and more cost-effective than the currently available and expensive drugs for multiple sclerosis (MS)? Experts weighed in on this topic at ACTRIMS Forum 2016, a recent meeting of the Americas Committee for Treatment and Research in Multiple Sclerosis.
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Migraine is the third most common medical condition and the eighth leading cause of disability worldwide, according to the World Health Organization; yet, migraines are still underdiagnosed and undertreated. The misdiagnosis of migraines is partly to blame for patients not receiving optimal care.
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  • Natalizumab Shows Efficacy versus Fingolimod in Relapsing-Remitting Multiple Sclerosis
  • Accuracy of Parkinson’s Disease Clinical Diagnosis Is Suboptimal
  • Study Examines Serious Adverse Events with Long-Term Sumatriptan in Patients with Chronic Cluster Headache
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Cerebrospinal fluid (CSF) biomarkers and cerebral beta-amyloid and amyloid positron emission tomography (PET) measures are equally accurate in the identification of early Alzheimer’s disease.
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Significant strides have been made in understanding the factors that influence cognitive decline in older adults. Multiple studies have found that the brain-derived neurotrophic factor (BDNF) may play a role in late-life cognitive impairment, particularly in the pathogenesis of Alzheimer’s disease. For example, beta-amyloid, which is increased in Alzheimer’s disease, may interact with BDNF and suppress its expression, resulting in impaired cognition.
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