VBCN - July 2014 Volume 1, No 2

Philadelphia, PA—Patients with breakthrough seizures despite adherence to antiepileptic drugs have much higher emergency department and inpatient utilization compared with patients without breakthrough seizures, according to a poster presented during the 2014 meeting of the American Academy of Neurology by Charles Makin, MS, MBA, Health Economics and Outcomes Research, IMS Health, and colleagues.
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Philadelphia, PA—Genomic sequenc­ing is starting to yield progress in unraveling the genetics of select forms of epilepsy, with some immediate clinical implications, said David B. Goldstein, PhD, Professor of Molecular Genetics, Microbiology, and Biology, and Director of the Center for Human Genome Variation, Duke University, Durham, NC, at the 2014 meeting of the American Academy of Neurology.
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Philadelphia, PA—Molecular subtyping and classification of patients for the selection of appropriate treatment and prognosis can now be used in routine clinical care in neurology, according to Teri Manolio, MD, PhD, Director, Division of Genomic Medicine, National Human Genome Research Institute, Rockville, MD, at the 2014 American Academy of Neurology meeting.
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Results of the largest study to evaluate the link between cognition and cortical thinning using 3T magnetic resonance imaging (MRI) show cortical thinning in patients with early-stage Parkinson’s disease (PD) that is associated with mild cognitive impairment (MCI) as reflected by lower cognitive function scores. This finding could lead to earlier diagnosis and treatment of PD, the researchers note.
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When administered early, intravenous tissue plasminogen activator (tPA), an enzyme that helps dissolve clots, reduces long-term disability in patients with stroke.
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The often-prescribed antidepressant citalopram (Celexa), a selective serotonin reuptake inhibitor (SSRI), appears to reduce the formation of amyloid plaques that are associated with Alzheimer’s disease, according to new research in mice and a small cohort of healthy individuals.
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Stroke mortality has seen a decline in recent years; however, trends in the incidence of intracerebral hemorrhage (ICH) remain unclear.
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A systematic review of existing quality measures for the emergency care of acute ischemic stroke has revealed that only 3 measures meet all of the American College of Cardiology (ACC)/American Heart Association (AHA) evaluation criteria.
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Philadelphia, PA—A protocol that identifies reversible or modifiable contributory factors to cognitive impairment when used in combination with the aggressive use of approved antidementia medications can improve the cognitive status of patients with dementia or mild cognitive impairment.
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Philadelphia, PA—Two investigational monoclonal antibodies against the calcitonin gene-related peptide (CGRP) proved safe and effective at preventing migraine in a pair of phase 2, placebo-­controlled, proof-of-concept trials, researchers reported at the 2014 American Academy of Neurology meeting.
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