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Epilepsy
Cognitive Outcomes in Children of Pregnant Women with Epilepsy
Epilepsy
August 2022
In 2-year-old children of women with epilepsy, no cognitive differences were seen compared with children of mothers without epilepsy.
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Newer Antiseizure Medications and the Risk of Suicidality
Epilepsy
August 2022
A recent meta-analysis of clinical trials for newer antiseizure medications found that the risk of suicidality was not increased compared with placebo.
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Lamotrigine versus Levetiracetam and Zonisamide for First-Line Therapy of Focal Epilepsy
Epilepsy
July 2022
Clinical effectiveness and cost-effectiveness may favor lamotrigine over newer antiseizure treatments levetiracetam and zonisamide for focal epilepsy.
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Levetiracetam Compared with Valproate for Generalized and Unclassifiable Epilepsy
Epilepsy
June 2022
In a study with important implications for first-line treatment of generalized epilepsy, particularly for women of childbearing age, investigators found that levetiracetam may not be as clinically effective or cost-effective as valproate for newly diagnosed generalized epilepsy.
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Safety of Diazepam Nasal Spray for Seizure Clusters in Patients Taking Maintenance Benzodiazepines
Epilepsy
May 2022
The safety profile for diazepam nasal spray for acute treatment of seizure clusters was similar with or without concomitant benzodiazepine therapy, according to the interim results of a phase 3 open-label safety study.
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Long-Term Follow-Up Study of Brivaracetam for Uncontrolled Focal Epilepsy
Epilepsy
April 2022
Brivaracetam as adjunctive therapy for focal seizures is safe, well-tolerated, and efficacious, according to the results of a long-term follow-up study of participants in earlier clinical trials.
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Early Intervention to Prevent First Seizures in Infants with Tuberous Sclerosis Complex
Epilepsy
March 2022
Initiating antiepileptic therapy in infants with tuberous sclerosis complex before their first seizure may delay the onset of seizures, according to a new study.
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Sleep Depth May Be Correlated with Heart Rate After Seizures During Sleep
Epilepsy
February 2022
For seizures that occur during sleep, deeper sleep in the 5 minutes preceding a seizure was correlated with a reduced heart rate after the seizure, according to a recent study.
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Timing of Epilepsy Onset Influences Type of Cognitive Impairment and Memory Deficits
By
Charles Bankhead
Epilepsy
VBCN - November 2016 Volume 3, No 3
Patients with early- versus late-onset epilepsy exhibited distinct differences in the origin of memory deficits, supporting the practice of subtyping patients by clinical characteristics to identify individualized predictors of cognitive dysfunction, according to the results of a new study.
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New Indications for Novel Antiepileptic Drugs May Offer Advantages for Patients with Seizures
By
Corbin Davis
Epilepsy
VBCN - July 2016 Volume 3, No 2
A survey of the newest antiepileptic drugs shows clinical progress and improved outcomes, but also room for improvement.
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