Epilepsy

The US Food and Drug Administration has approved fenfluramine for difficult-to-treat seizures in patients with Lennox-Gastaut syndrome.
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A network meta-analysis of 5 third-generation antiseizure medications found that cenobamate was likely to have the best efficacy, and brivaracetam and lacosamide were likely to have the best tolerability.
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A study analyzed the incidence and cognitive and functional outcomes of posttraumatic epilepsy in patients with traumatic brain injury.
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Patients with adult-onset epilepsy who took enzyme-inducing antiseizure medications had a higher hazard of incident cardiovascular disease.
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In 2-year-old children of women with epilepsy, no cognitive differences were seen compared with children of mothers without epilepsy.
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A recent meta-analysis of clinical trials for newer antiseizure medications found that the risk of suicidality was not increased compared with placebo.
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Clinical effectiveness and cost-effectiveness may favor lamotrigine over newer antiseizure treatments levetiracetam and zonisamide for focal epilepsy.
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In a study with important implications for first-line treatment of generalized epilepsy, particularly for women of childbearing age, investigators found that levetiracetam may not be as clinically effective or cost-effective as valproate for newly diagnosed generalized epilepsy.
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The safety profile for diazepam nasal spray for acute treatment of seizure clusters was similar with or without concomitant benzodiazepine therapy, according to the interim results of a phase 3 open-label safety study.
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Brivaracetam as adjunctive therapy for focal seizures is safe, well-tolerated, and efficacious, according to the results of a long-term follow-up study of participants in earlier clinical trials.
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